A race around Central and South America in which eleven Latin American couples compete to arrive in first place to the final pit stop to win US$250,000. Each team has to complete each leg of the race as quickly as possible as the last team to arrive to the pit stop will be eliminated. Tensions arise between the participants as they try to complete each task to continue in the race.
Harris Whitebeck hosts the first three seasons of the show. Season 5 is hosted for the first time by a woman, Colombian model and former participant of The Amazing Race Latin America Season 3, Toya Montoya.